SYNERGISTIC INHIBITION OF THE HEDGEHOG PATHWAY BY NEWLY DESIGNED SMO AND GLI ANTAGONISTS BEARING THE ISOFLAVONE SCAFFOLD

M. CAIMANO, S. BERARDOZZI, F. BERNARDI, P. INFANTE, C. INGALLINA, S. TOSCANO, E. DE PAOLIS, R. ALFONSI, B. BOTTA, M. MORI, F. GHIRGA, L. DI MARCOTULLIO

PDF(218 KB)
Journal of Biological Regulators and Homeostatic Agents ›› 2018, Vol. 32 ›› Issue (4(S1)) : 148-148.

SYNERGISTIC INHIBITION OF THE HEDGEHOG PATHWAY BY NEWLY DESIGNED SMO AND GLI ANTAGONISTS BEARING THE ISOFLAVONE SCAFFOLD

Author information +
History +

Abstract

The Hedgehog (Hh) signalling pathway is evolutionarily conserved and its fine regulation is essentialfor proper development and tissues homeostasis. Aberrant activation of the Hh pathway is responsiblefor the onset of several malignancies, including medulloblastoma (MB), the most frequent pediatricbrain tumor. Small molecules able to block the pathway at the upstream receptor Smoothened (Smo) orthe downstream effector Gli1 have thus emerged recently as valuable anticancer agents. The aim of thisproposal is to discover novel powerful Smo and Gli inhibitors targeting Hh signaling at both upstreamand downstream level, and to investigate their pharmacological effects on MB.

Cite this article

Download Citations
M. CAIMANO , S. BERARDOZZI , F. BERNARDI , P. INFANTE , C. INGALLINA , S. TOSCANO , E. DE PAOLIS , R. ALFONSI , B. BOTTA , M. MORI , F. GHIRGA , L. DI MARCOTULLIO. SYNERGISTIC INHIBITION OF THE HEDGEHOG PATHWAY BY NEWLY DESIGNED SMO AND GLI ANTAGONISTS BEARING THE ISOFLAVONE SCAFFOLD. Journal of Biological Regulators and Homeostatic Agents. 2018, 32(4(S1)): 148-148

References

RIGHTS & PERMISSIONS

Copyright © 2018 by BIOLIFE, s.a.s. This publication and/or article is for individual use only and may not be further reproduced without written permission from the copyright holder. Unauthorized reproduction may result in financial and other penalties. DISCLOSURE: ALL AUTHORS REPORT NO CONFLICTS OF INTEREST RELEVANT TO THIS ARTICLE.
Article Options
  • PDF (1 views)
  • Full Text (73 views)

73

Accesses

0

Citation

Detail

Sections
Recommended

/